Cardiovascular, Renal and Metabolism (CVRM)皇冠官网网站
Up to 20 million 皇冠注册官网地址
people die from CVRM diseases each year, making them the leading causes of death across the globe5,6
Up to 94% 皇冠注册官网地址
of people with type-2 diabetes in the US have at least one other cardiovascular, renal or metabolic condition7
of patients with heart failure also have chronic kidney disease8
Up to 40%皇冠注册官网地址
of patients hospitalised for heart failure have diabetes9
Know the Danger皇冠官网网站
Up to 94% of people with type-2 diabetes in the US have at least one additional CVRM condition.7 We work to provide solutions for these complications that might become life-threatening, to change the lives of type-2 diabetes patients by reducing risk factors through early prevention. We aim to raise awareness of common comorbidities and inspire healthcare professionals and patients alike to get involved in our holistic approach towards disease management.
Up to one in five people who have been event-free for a year may experience another heart attack within three years of the first.10 Working together with healthcare professionals, we help raise awareness of the importance of secondary prevention among heart attack survivors.
Chronic kidney disease infographic皇冠官网网站
Chronic kidney disease occurs in the context of multiple comorbidities and has been termed as a “disease multiplier.”11 We work to find ways to help patients manage the many complications and provide solutions for better disease management.
Atacand, Atacand HCT, Atacand Plus皇冠官网网站
saxagliptin and metformin HCl
saxagliptin and metformin XR
Sodium zirconium cyclosilicate
Plendil, Modip, Splendil, Munobal, Flodil 皇冠官网网站
dapagliflozin and saxagliptin
Seloken ZOK, Toprol-XL, Betaloc ZOK皇冠官网网站
Tenormin, Tenormine, Prenormine, Atenol 皇冠官网网站
dapagliflozin and metformin HCI
XIGDUO XR 皇冠官网网站
dapagliflozin and metformin HCI extended-release
We follow the science to develop innovative treatments and ultimately, modify or even halt the natural course of the disease and regenerate organs. We are agnostic to drug modality, we identify and validate novel targets based on genetics and human target validation and then apply the best modality to modulate the target. Together with key experts throughout the world we collaborate to accelerate our scientific progress, and to further define patient populations that may benefit from the novel cardio-renal-metabolic therapies we are developing.
Phase III/LCM Projects: refers to assets that are pivotal in Phase II/III, or that have been submitted for regulatory approval, and may include assets that are now launched in one or more major markets (removed when launched in all applicable major markets).
Healthy Heart Africa is committed to tackling hypertension and the increasing burden of cardiovascular disease (CVD) in Africa. Since launching in Kenya in 2014, then Ethiopia in 2016, Tanzania in 2018 and Ghana in 2019, we have conducted over 11 million blood pressure screenings; identified over 2 million elevated readings; trained over 5,800 healthcare workers; and activated over 700 healthcare facilities.12 In support of the United Nations targets to reduce the risk of premature death from NCDs,13 we aspire to reach 10 million people with elevated blood pressure across Africa by 2025.
Know more about Healthy Heart Africa
Supported by the American Heart Association (AHA) and AstraZeneca, One Brave Idea (OBI) aims to understand the molecular events surrounding the earliest transition from wellness to disease in coronary heart disease (CHD). OBI is turning its focus upstream and seeking out earlier changes in the development of CHD, working outside the constraints of traditional biomedical science. Through an agile approach, multidisciplinary team and unique organisational structure, OBI is paving the way for innovative research.
The American Heart Association (AHA), in partnership with the Chinese Society of Cardiology (CSC), initiated Improving Cardiovascular Care in China (CCC) in 2014. A multi-year project, CCC is designed to promote implementation of atrial fibrillation (AFib) and acute coronary syndrome (ACS) guidelines, and thereby improve outcomes for inpatients with AFib and ACS. CCC is a turning point for AFib and ACS care in China, facilitating effective guideline compliance and quality execution through best practice initiatives and training.
1. Bjornstad et al. Curr Opin Endocrinol Diabetes Obes. 2014 August ; 21(4): 279–286. doi:10.1097/MED.0000000000000074.
2. Narisa Futrakul, Ankanee Chanakul, Prasit Futrakul & Tawatchai Deekajorndech (2015) Early stage of vascular disease and diabetic kidney disease: an underrecognized entity, Renal Failure, 37:8, 1243-1246, DOI: 10.3109/0886022X.2015.1073054
3. Liviu Segall, Ionut Nistor, and Adrian Covic, “Heart Failure in Patients with Chronic Kidney Disease: A Systematic Integrative Review,” BioMed Research International, vol. 2014, Article ID 937398, 21 pages, 2014. https://doi.org/10.1155/2014/937398.
4. Edelman Intelligence Relevance and barriers amongst EU specialists Survey 2018. Document ID: Z2-0050 | Date of preparation: August 2018 | Date of expiry: July 2020
5. Wang H et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet 2016; 388(10053):1459–544.
6. World Health Organization. (2019). World Heart Day. [online] Available at: https://www.who.int/cardiovascular_diseases/world-heart-day/en/ [Accessed 31 Jul. 2019].
7. Arnold SV et al. Burden of cardio-renal-metabolic conditions in adults with type 2 diabetes within the Diabetes Collaborative Registry. Diabetes Obes Metab 2018; 20(8):2000–3.
8. Shiba N, Shimokawa H. Chronic kidney disease and heart failure--Bidirectional close link and common therapeutic goal. J Cardiol 2011; 57(1):8–17.
9. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. European Heart Journal (2013) 34, 3035–3087 doi:10.1093/eurheartj/eht108
10. JernBerg T et al. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective. Eur Heart J 2015; 36:1163-1170.
11. National Institute of Diabetes and Digestive and Kidney Diseases. Kidney Disease Statistics for the United States: December 2016. National Institutes of Health [cited 2018 Aug 28]. Available from: URL: https://www.niddk.nih.gov/health-资讯rmation/health-statistics/kidney-disease.
12. AstraZeneca data on file. Programme screening and treatment & Total programme KPIs. June 2019.
13. R.L. Sacco et al. The Heart of 25 by 25: Achieving the Goal of Reducing Global and Regional Premature Deaths from Cardiovascular Diseases and Stroke. Circulation 2016; 133:e674-e690. Available at: https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000395 Last accessed July 2019.
Veeva ID: Z4-23524
Date of next review: July 2021